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Motilent Technology Overview

A brief overview of Motilent's core technology

GIQuant

About Motilent

Motilent is a technology startup with the goal of maximising the value of MRI for the investigation of gastrointestinal disease. We would like to find collaborators interested in using our technology to expand our collective understanding of the digestive system. This page provides an overview of some of our technology and introduces potential uses.

  Dynamic small bowel MRI scan

Dynamic small bowel MRI scan

Post processing

Manual assessment is possible but time consuming and we have developed registration technology called GIQuant to help speed up and automate motility assessment. GIQuant is used in single regions of interest to inspect inflammatory lesions in Crohn's disease where low motility is often a sign of disease.

  Normal motile terminal ileum in IBD subject

Normal motile terminal ileum in IBD subject

  Abnormal static terminal ileum in IBD subject

Abnormal static terminal ileum in IBD subject

Regional & Global assessment

GIQuant can also be used to assess global or segmental bowel motility. In the color-plots below we can see high and low motility at the terminal ileum corresponding to the motility series above. Global assessment in conditions like diabetic neuropathy, pseudo-obstruction or Hirschprung's can be assessed by placing a region of interest across the whole bowel.

  Motility map depicting good motility at the terminal ileum (corresponding to motility series above)

Motility map depicting good motility at the terminal ileum (corresponding to motility series above)

  Motility map depicting low motility at the terminal ileum (corresponding to motility series above)

Motility map depicting low motility at the terminal ileum (corresponding to motility series above)

Regional Assessment

Using a combination of image registration and insights from conventional high-resolution manometry, spatio-temporal mapping of the GI tract can be performed to provide detail on how the bowel is contracting.

  Semi-automated spatio-temporal mapping technique used in the stomach

Semi-automated spatio-temporal mapping technique used in the stomach

 
  Spatio-temporal map of gastric motility

Spatio-temporal map of gastric motility

 

Supporting robust research

MRI and GIQuant is being used in a growing number of studies to explore dysmotility in both health and disease. It is our hope that insights from MRI will soon be pared with clinical treatment strategies and are committed to supporting research in this area. Please do not hesitate to get in touch to find out more.

 

Contact: alex.menys@motilent.co.uk

Address: IDEALondon, London, EC2A 2BB, UK